Comparative Study of a Drug Release from a Textile to Skin
Authors: C. D. Radu, O. Parteni, M. Popa, I. E.Muresan, L. Ochiuz, L. Bulgariu, C., Munteanu, B.Istrate and E.Ulea,
J. Pharm. Drug Deliv. Res. 2015, 4:2, http://dx.doi.org/10.4172/2325-9604.1000134, FI=1.84
Objective: The achievement of a therapeutic dose of the hydrocortisone acetate (HCr) or coetaneous affections by using: i) a cyclodextrine derivative and ii) a hydrogel, in the systems fixing the drug on a textile material and then releases it in vitro towards the dermis under the action of a perspiration kit.
Methods: The formation of a temporary deposit of HCr on a cotton knitted fabric in the variants: 1) covalent grafting with monochloro triazinyl-beta-cyclodextrine (MCT-β-CD) by complexation in the hydrophobic cavity of the CD; 2) through the inclusion of Na2SO4 in ionic crosslinked chitosan-based hydrogel. Upon the release of HCr in vitro, a perspiration kit has been used.
Results: The two medicine release systems can release the therapeutic dose for coetaneous disorders.
Conclusion: The comparison of the two systems improves the understanding of the release mechanisms which may provide useful insights when designing medical textiles.
Cotton knitted fabric; Monochloro triazinyl-β-CD; Hydrogel; Chitosan; Therapeutic dose; Coetaneous disorder; Drug release.
A project co-funded by the European Commission under the 7th Framework Programme within the NMP thematic area.