Achievements and Limits on the Controlled Release of a Drug from a Textile Fabric to Dermis

Radu Cezar-Doru1,*, Popa Marcel1, Parteni Oana1, Salariu Mihaela1, Lupușoru Elena-Ctlina2, Ghiciuc Cristina2, Foia Liliana2, Chiriac Anca2, Lupusoru Raoul2, Oproiu Loti3 and Ulea Eugen4
1Technical University Iasi, street Mangeron 29, Romania
2University of Medicine and Pharmacy Iai, Romania
3ICECHIM Institute Bucharest, Romania
4University of Agricultural Sciences and Veterinary Medicine Iasi, Romania

Abstract:

The paper presents the overall results of theoretical achievements and experimental details when designing a
material for a textile fabric, which releases a drug for a specific pathology. It presents the conclusions of the researches on
the development of textile support as an anti-allergic, anti-fungal and anti-psoriasis type, but also on toxicological,
biocompatibility and therapeutic issues for establishing the amount of drug needed for the trans-dermal diffusion. This
paper estimates the possibility of applying a cyclodextrin (Cyc) on a textile surface to form temporary reservoirs by
complexing and subsequently releasing the drug under the action of cutaneous stimuli. One refers to the achievements of
authors, and works submitted by other research groups in the area of textile substrates used as implant or underwear worn
next to the skin. The results are analyzed both as a scientific communication and the possible application for a potential
current industrial processing.

Keywords: Cutaneous pathologies, cyclodextrin, drug release, hydrogels, matrices, textile fabric.